South Carolina’s cities each have their own rhythm—a blend of heritage and innovation, nature and nightlife, flavor and flair. From the Blue Ridge foothills to the breezy Lowcountry, these five signature cities capture the essence of the Palmetto State. Explore rich stories, dynamic culture and surprising detours just beyond the main roads.
Essential Experiences in South Carolina’s Signature Cities
Where Culture Meets the Falls
Centered around the cascading beauty of Falls Park on the Reedy, Greenville pulses with artistic energy and small-city charm. World-class performances light up the Peace Center, while signature festivals like euphoria and Artisphere transform downtown into a lively open-air celebration of food, music and visual arts. The 28-mile Swamp Rabbit Trail threads it all together, connecting neighborhoods, breweries and the vibrant Unity Park, where kids cool off in splash fountains and climb all-ages play structures designed for accessibility.
Greenville’s culinary scene is just as diverse as it is delightful. Southern staples shine, but global flavors take center stage; gather around the communal table at Keipi for Georgian-style feasts, savor richly spiced lamb at Aryana Afghan Cuisine or indulge in Persian lemon-saffron chicken and pomegranate martinis at Pomegranate on Main.
For your stay, take your pick between a number of luxe lodging options, such as Grand Bohemian Lodge—an upscale mountain-lodge-inspired retreat nestled within Falls Park—or Hotel Hartness, a serene escape set on 180 acres of rolling woodland just beyond downtown.
5 Unexpected Detours
Topsoil Kitchen & Market, Travelers Rest
With a 16-acre farm, this James Beard-nominated treasure touts seasonal, hyper-local fare.
Taylors Mill, Taylors
This century-old textile mill turned creative enclave hosts artists, craft brews and arcade games.
The Silos, Easley
Converted grain silos house live music and vendors serving international street food, sweet snacks and craft beer.
Upstate Pinball & Arcade Museum, Simpsonville
Over 60 classic pinball machines and vintage video arcade games mean all-ages fun.
Cedar Falls Park, Fountain Inn
Scenic trails, historical mill remnants and waterfalls on the Reedy River beckon.
Myrtle Beach
High-Energy, High-Fun
Myrtle Beach is made for memory-making. Stroll the lively stretch of Broadway at the Beach, where theatrical shows, ball games, go-karts, mini-golf, wildlife exhibits and water slides offer nonstop fun for all ages. Many attractions, including Ripley’s Aquarium and Sky Zone, feature sensory-friendly options for inclusive adventures.
Car lovers can ogle vintage muscle cars and memorabilia at Wheels of Yesteryear then head to Redline Simcade in Surfside Beach for high-speed virtual reality racing thrills.
Craving robust flavors with ocean views? Dig into creamy chipotle shrimp chimichangas or blackened mahi tacos at Salt & Lime or check out Guy Fieri’s Downtown Flavortown, slated to open in 2026, which will be home to a tiki bar, bowling alley and arcade all under one wild roof.
For a break from the bustle, kick back and sip craft brews at New South Brewing, or explore the powerful stories at The Historic Myrtle Beach Colored School Museum & Education Center.
Ride the SkyWheel for glowing sunset views, then head up to North Myrtle Beach for beachy tunes at Fat Harold’s Beach Club, an institution since 1955 and the home of South Carolina’s state dance, the Shag.
5 Unexpected Detours
Atalaya Castle, Murrells Inlet
Visit this oceanside castle, once home to a world-renowned sculptor.
World Famous Blue Crab Festival, Little River
May 16–17, get your fill of fresh shellfish and fishing-village charm.
Rivertown Bistro, Conway
Taste inventive, Southern-inspired global dishes by South Carolina Chef Ambassador Darren Smith.
The Hammock Shops Village, Pawleys Island
Charming shops beneath moss-draped trees tout beachy fashions and gifts.
Mansfield Plantation, Georgetown
Experience a centuries-old estate at this 1700s rice plantation and filming site of The Patriot.
Charleston
Timeless, Tasteful and Always in Bloom
Charleston is pure cinematic charm: pastel-painted mansions along Rainbow Row, centuries-old oaks at Middleton Place (home of a Declaration of Independence signer) and quaint cobblestone streets. But this city doesn’t just preserve the past—it continually reimagines the present. Explore bold perspectives at the International African American Museum or discover contemporary creativity at The Gibbes Museum of Art.
The food scene is just as inspired. Savor edible art at the omakase-style Raw Lab, go bold with spicy Sichuan dishes at Kwei Fei, savor premium cuts of steak at Marbled & Fin or indulge in Southern-style seafood at James Beard-nominated Chubby Fish or Tripadvisor Travelers' Choice Awards-winner Revival. Anchor your visit with marquee events like Art Charleston or Charleston Wine + Food, which infuse even more culture into the mix.
Stay in style with riverfront suites at The Cooper or the chic new Hotel Richemont downtown. Then, let the day drift to a close with a golden-hour sail aboard the Schooner Pride.
5 Unexpected Detours
Striped Pig Distillery, North Charleston
Take a tour and taste house-distilled spirits such as Striped Southern Pecan Bourbon whiskey.
Stono Market & Tomato Shed Café, Johns Island
Dig into fresh Lowcountry fare in a market-meets-diner setting.
Caw Caw Interpretive Center, Ravenel
Over 6 miles of trails and marsh boardwalks reward birders and wildlife watchers.
Charleston Artist Collective, Mount Pleasant
Shop for local works at this art gallery brimming with indie flair.
Columbia
Heart of the Palmetto State
Columbia strikes a bold balance—capital city meets college-town cool, with a creative streak all its own. Explore preserved mansions, storied neighborhoods and important African American history sites with Historic Columbia tours, or soak up river views when you meander along the scenic West Columbia Riverwalk Park. Swing by the South Carolina State House for a free tour of its grand architecture and radiant stained glass, then toast the town with rooftop cocktails at Moxy Columbia Downtown. Then indulge in French fare and fine wine at Hampton Street Vineyard.
The city hums with local pride at events like the Saturday morning Soda City Market, named #1 Farmers Market in the country by USA Today's 10Best Readers' Choice Awards. At the Cottontown Art Crawl, artists, vendors, musicians and food trucks take over the streets. Don’t miss the Columbia International Festival, a colorful celebration of global cultures and cuisines.
When the sun sets, The Vista district comes alive. Catch live music at Tin Roof, sip thoughtfully curated vintages at Lula Drake Wine Parlour or go wild with woodsy, elevated dishes like elk bolognese at The Hollow.
5 Unexpected Detours
Congaree National Park, Hopkins
Experience towering trees, boardwalk trails, kayak routes and synchronous fireflies (May/June).
Harbison State Forest, Columbia
Find 18 miles of hiking and biking trails, plus free programming, just minutes from downtown.
Little Mountain Unlimited, Little Mountain
Explore quirky antiques and hidden treasures, then grab lunch at the on-site cafe.
Laura’s Tea Room, Ridgeway
Enjoy a midday spot of tea with warm scones and Devonshire cream.
Terror Falls Haunted Farm, Gaston
Four spooky attractions bring seasonal thrills and chills.
Hilton Head Island
Hilton Head Island doesn’t rush. It invites you to slow down and savor. Start your day with a sunrise stroll along the wide, quiet sands of Folly Field Beach Park, which also offers beach matting for wheelchair access. Embark on a dolphin-watching cruise from Shelter Cove Harbour & Marina, where you also can browse coastal-inspired boutiques, dine on the waterfront and catch a seasonal fireworks show. Dive deeper into the island’s natural and cultural heritage at the free Coastal Discovery Museum, a Smithsonian affiliate with historical exhibits, nature trails and the kick-off spot for Gullah Heritage Trail Tours.
In spring, sip and savor your way through the Hilton Head Island Food & Wine Festival, or return in the fall for the fast-paced excitement of the Multi Hull Beach Regatta.
Tee off at The Sea Pines Resort's Harbour Town Golf Links, the famed Pete Dye course and home of the RBC Heritage Presented by Boeing, a PGA TOUR event, or just enjoy the view from the clubhouse. For dinner, indulge in seafood served everywhich-way at waterfront spots such as Skull Creek Boathouse and Benny’s Coastal Kitchen, and then kick back with concerts, lawn games and craft beers at The Bank.
5 Unexpected Detours
Bluffton Gullah Cultural Heritage Center, Bluffton
Celebrate the vibrant traditions and stories of the Gullah Geechee community.
Sergent Jasper Park, Hardeeville
Bring the family for tranquil trails, fishing, boating, birdwatching and disc golf at this 321-acre park.
Carolina Cider Company & Clockwise Coffee, Yemassee
Stock up on local cider, pastries, sweets and sips at this rustic roadside shop.
The Iron Fish Gallery, Daufuskie Island
Explore coastal inspired metalworks by artist Chase Allen.
Merrick Daffodil Farm, Bluffton
Pick your own springtime bouquet at this seasonal, family-owned daffodil farm.
